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  1. #01

    Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer

    eLife · 2026

    100%Recommend5 reader responses

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Recommendations and reservations

Each point is one paper. Position reflects reader responses, not scientific validity.

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Recommendations and reservationsEach point is one paper. Position reflects reader responses, not scientific validity.012345012345RecommendWould not recommendTurnover Modulates the Need for a Cost of Resistance in Adaptive Therapy — 1 Recommend; 0 Would not recommendResting-state spatial statistics of NK cell receptors may improve early signal discrimination — 0 Recommend; 1 Would not recommendCell-mechanical parameter estimation from 1D cell trajectories using simulation-based inference — 1 Recommend; 1 Would not recommendThe Power of Three: Nanomaterials for Natural Killer (NK) Cell Immunoengineering Maximize Their Potency if They Exploit Multireceptor Stimulation — 0 Recommend; 1 Would not recommendMachine Learning‐Driven Nanopore Sensing for Quantitative, Label‐Free miRNA Detection — 0 Recommend; 1 Would not recommendA likelihood-based Bayesian inference framework for the calibration of and selection between stochastic velocity-jump models — 2 Recommend; 0 Would not recommendA novel transformer-based platform for the prediction and design of biosynthetic gene clusters for (un)natural products — 1 Recommend; 1 Would not recommendThe frontier of simulation-based inference — 2 Recommend; 2 Would not recommendFrequent genetic alterations in myositis autoantigen genes in cancer-associated dermatomyositis — 0 Recommend; 1 Would not recommendRecent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer — 1 Recommend; 0 Would not recommendProtein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells — 1 Recommend; 1 Would not recommendTaking the biology seriously makes models better — 5 Recommend; 0 Would not recommendIntratumoral T reg cell ablation elicits NK cell–mediated control of CD8 T cell–resistant tumors — 0 Recommend; 2 Would not recommendDDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development — 1 Recommend; 0 Would not recommendProgrammable mesoporous carbon architectures from liquefied wood via reactive-emulsion-mediated self-assembly — 1 Recommend; 1 Would not recommendBrain-cognition relationships and treatment outcome in treatment-resistant late-life depression — 0 Recommend; 1 Would not recommend
Papers
16
Responses
29
Recommend share
55%
Pearson r
-0.40
Inspect and sort papers
PaperRecommendWould not recommendBalance
Taking the biology seriously makes models better505
The frontier of simulation-based inference220
A likelihood-based Bayesian inference framework for the calibration of and selection between stochastic velocity-jump models202
A novel transformer-based platform for the prediction and design of biosynthetic gene clusters for (un)natural products110
Cell-mechanical parameter estimation from 1D cell trajectories using simulation-based inference110
Intratumoral T reg cell ablation elicits NK cell–mediated control of CD8 T cell–resistant tumors02-2
Programmable mesoporous carbon architectures from liquefied wood via reactive-emulsion-mediated self-assembly110
Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells110
Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression01-1
DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development101
Frequent genetic alterations in myositis autoantigen genes in cancer-associated dermatomyositis01-1
Machine Learning‐Driven Nanopore Sensing for Quantitative, Label‐Free miRNA Detection01-1
Recent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer101
Resting-state spatial statistics of NK cell receptors may improve early signal discrimination01-1
The Power of Three: Nanomaterials for Natural Killer (NK) Cell Immunoengineering Maximize Their Potency if They Exploit Multireceptor Stimulation01-1
Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy101

A paper receives a numbered rank after five responses from distinct reader accounts.

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