Genetics and genomicsClinical medicineCell biology

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis

Jingan Chen, Muye Zhou, Songtao Dong, Fanglin Gong, et al.

Journal
Science
Published
2026
DOI
10.1126/science.aeb0054
Subjects
Genetics and genomicsClinical medicineCell biology

Chemically modified suppressor tRNAs and pulmonary lipid nanoparticles are combined to rescue cystic-fibrosis nonsense mutations.

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